YELLOW FEVER VACCINE

• Immunisation against yellow fever

Given as a deep SC injection.

• Children under 6 months
• History of thymus dysfunction
• Hypersensitivity to eggs or chicken proteins
• History of serious hypersensitivity to yellow fever vaccine
• HIV infection
• Current severe febrile illness

• Headache
• Nausea, vomiting, diarrhoea
• Muscle pain
• Weakness
• Injection site reactions
• Fever

• Azathioprine (impairment of immune response; avoid concomitant use)
• Ciclosporin (impairment of immune response; avoid concomitant use)
• Corticosteroids (high doses of corticosteroids impair immune response; avoid concomitant use)

• Do not use.

• Do not use.

• Store at 2– 8°C. Do not freeze. Protect from light.
• Use immediately after reconstitution.

• Should not be given during pregnancy, but if significant risk of exposure cannot be avoided, then delay vaccination to the third trimester if possible (but the need for immunisation usually outweighs risk to the foetus).
• In breast-feeding, only use vaccine if mother is at a real risk of yellow fever disease.
• Do not mix with another vaccine or medicinal product in the same syringe. If there is a need to inject another vaccine at the same time, use separate sites.
• Do not give to HIV-positive people. Seek specialist advice if yellow fever risk is unavoidable.
• Immunity starts from 10 days after primary immunization up to about 10 years.