Vecuronium Bromide

Dosage Forms

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Powder for solution for injection

10 mg

Uses

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Neuromuscular blockade

Dose and Duration

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Neuromuscular blockade

Adult and child over 1 month: initially, 0.08–0.1 mg /kg by IV injection, then maintenance dose of 0.02–0.03 mg/kg (max 0.1 mg/kg in caesarean section) by IV injection or 0.8–1.4 μg/kg/minute by IV infusion, adjusted according to response.

Neonate: 0.08 mg/kg by IV injection, then maintenance dose of 0.03–0.05 mg/kg by IV injection or 0.8–1.4 μg/kg/minute adjusted according to response.

Preparation

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Reconstitute each vial with 5 ml water for injections to give 2 mg/ml solution; alternatively reconstitute with up to 10 ml glucose 5% or sodium chloride 0.9% or water for injections.
Solutions reconstituted without water for injections are unsuitable for further dilution.
For continuous intravenous infusion, dilute to a concentration up to 40 micrograms/ml.

Contraindications

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Hypersensitivity to rocuronium or bromide

Side Effects

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Changes in vital signs
Prolonged neuromuscular block
Anaphylactic and anaphylactoid reactions

Interactions

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Aminoglycosides (effect of vecuronium enhanced)

Pregnancy

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Can be used.

Breastfeeding

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Can be used.

Storage

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After reconstitution, store at 2–8°C for not ≥ 24 hours.

⚠️ Caution

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Use with caution in significant renal failure and hepatic impairment.
Use with caution in patients with hypersensitivity to other neuromuscular blocking medicines.
Patients with burns may require higher doses due to resistance to vecuronium.
Use lower doses in hyperthermia and myasthenia gravis.
Calculate doses on basis of ideal body weight in obese patients.
Duration of action is shorter in children, therefore maintenance doses are required more frequently.
Vecuronium causes paralysis of respiratory muscles therefore respiratory support is required until adequate spontaneous respiration is restored.