VASOPRESSIN

An endogenous hormone with a direct antidiuretic effect on the kidney; it is given in the synthetic form of argipressin.

Dosage Forms

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Solution for injection

Argipressin 20 units per 1ml

Uses

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  • Pituitary diabetes insipidus
  • Upper GI bleeding
  • Septic shock

Dose and Duration

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Pituitary diabetes insipidus

By intramuscular or subcutaneous injection

Adult: 5–20 units every 4 hours
Upper GI bleeding

By intravenous infusion

Adult:20 units, dose to be administered over 15 minutes
Septic shock

By Intravenous infusion

Adult:0.03 - 0.04units/min

Contraindications

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  • Chronic nephritis (until reasonable blood nitrogen(BUN) concentration is attained)
  • Vascular disease(especially coronary artery disease)

Side Effects

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  • Abdominal pain
  • Angina pectoris
  • Hypertension
  • Hyperhidrosis
  • Bronchospasm

Pregnancy

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  • Oxytocic effect in third trimester

Breastfeeding

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  • Not known to be harmful.

⚠️ Caution

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  • Avoid in fluid overload
  • In conditions which might be aggravated by water retention like heart failure and hypertension