SEVOFLURANE

• Induction of anaesthesia
• Maintenance of anaesthesia

Give in oxygen or nitrous oxide-oxygen using a specially calibrated vaporiser and doses adjusted according to response.

• Known or suspected hypersensitivity to sevoflurane or other halogenated anaesthetics
• History of hepatitis induced by halogenated inhalational anaesthetic
• Genetic susceptibility to malignant hyperthermia

• Agitation, somnolence, headache
• Bradycardia, tachycardia, hypotension, hypertension
• Nausea, vomiting, salivary hypersecretion
• Chills, pyrexia, hypothermia
• Abnormal blood glucose and liver function tests
• Anaphylactic reactions

• Levodopa, doxapram, adrenaline, noradrenaline (increased risk of arrhythmias)
• Methylphenidate (increased risk of hypertension)

• Do not use

• Can be used

• May depress neonatal respiration if used during delivery
• Breast-feeding can be resumed as soon as mother has sufficiently recovered from anaesthesia
• Patients may require early post-operative pain relief since emergence following sevoflurane is fairly rapid
• Use with caution in patients with coronary disease, seizures, renal impairment or down syndrome