REMIFENTANIL

Adult and child over 12 years: by IV infusion, 30–60 micrograms/kg/hour, with or without an initial dose by IV injection of 0.25–1 micrograms/kg over at least 30 seconds

Elderly: starting dose, ½ adult dose adjusted according to response

Adult and child over 12 years: initially 0.1–1 micrograms by IV injection if required, then 3–12 micrograms/kg/hour by IV infusion according to anaesthetic technique used and adjusted according to response. In light anaesthesia, give supplemental doses by IV injection every 2–5 minutes

Elderly: starting dose, ½ adult dose adjusted according to response

Child 1 month–12 years: initially by IV injection 0.1–1 micrograms/kg over at least 30 seconds (omit if not required) then by IV infusion 0.05–1.3 micrograms/kg/minute according to anaesthetic technique and adjusted according to response. Additional doses can be given by IV injection during infusion

Neonate: by IV infusion 0.4–1 micrograms/kg/minute. Additional doses of 1 microgram/kg can be given by IV injection during the infusion

Adult: by IV infusion, initially 2.4 micrograms/kg/hour adjusted according to response, usual dose range 1.5–6 micrograms/kg/hour

Elderly: starting dose, ½ adult dose adjusted according to response

Adult over 18 years: for max 3 days, by IV infusion, initially 6–9 micrograms/kg/hour adjusted according to response in steps of 1.5 micrograms/kg/hour at intervals of at least 5 minutes. Usual range 0.36–44.4 micrograms/kg/hour. If an infusion rate of 12 micrograms/kg/hour does not produce adequate sedation add another sedative (consult product literature)

Adult over 18 years: by IV infusion, maintain infusion rate of at least 6 micrograms/kg/hour for at least 5 minutes before procedure and adjust every 2–5 minutes according to requirements, usual range 15–45 micrograms per kg/hour