Solution for Injection
10 mg/ml
Dosage Forms
Uses
Dose and Duration
Reversal of over dosage with intravenous injection of
unfractionated heparin
Administer by slow IV injection at a rate not exceeding 5 mg/ minute (max 50 mg)
| Time since heparin (min) | Dose of protamine (adult and child) |
|---|---|
| 0–15 | 1 mg neutralizes 100 IU |
| 15–30 | 1 mg neutralizes 100 IU |
| 30–60 | 0.5–0.75 mg neutralizes 100 IU |
| 60–120 | 0.375–0.5 mg neutralizes 100 IU |
| Over 120 | 0.25–0.375 mg neutralizes 100 IU |
Reversal of over dosage with intravenous infusion of
unfractionated heparin
Adult: stop infusion of heparin, then administer 25–50 mg of protamine by slow IV injection
Child 1 month–18 years: dose same as for over dosage of heparin by intravenous injection
Reversal of over dosage with subcutaneous injection of
unfractionated heparin
Adult: 1 mg of protamine neutralises 100 IU of heparin. Administer 25–50 mg by slow IV injection then the remaining dose by IV infusion over 8–16 hours
Child 1 month–18 years: 1 mg neutralises 100 IU of heparin. Give 50–100% of total dose by IV injection then the remainder by IV infusion over 8–16 hours
Reversal of over dosage with subcutaneous injection of low
molecular weight heparin
Adult and child: 1 mg neutralizes 100 IU by intermittent IV injection or by continuous IV infusion (consult product literature)