PIPERACILLIN WITH TAZOBACTAM

Piperacillin, a ureidopenicillin, is only available in combination with the beta-lactamase inhibitor tazobactam.

Dosage Forms

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Powder for Reconstitution for Injection

Piperacillin 2g/Tazobactam 250mg
Piperacillin 4g/Tazobactam 500mg

Uses

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  • Impetigo
  • Septicaemia
  • Complicated infections involving the urinary-tract
  • Severe diabetic foot infection

Dose and Duration

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All Infections

By Intravenous infusion

Adult: 4.5g every 8 hours. Increase if necessary to 4.5g every 6 hours. Increased frequency maybe used for severe infections

Contraindications

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  • Hypersensitivity to penicillins

Side Effects

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  • Anemia
  • Candida infections
  • Diarrhoea, nausea, vomiting
  • Epistaxis, stomatitis
  • Eosinophilia, pancytopenia

Pregnancy

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  • Manufacturers advise use only if potential benefit outweighs risk

Breast-feeding

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  • Trace amount in milk, but appropriate to use.

⚠️ Caution

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  • High doses may lead to hypernatraemia (owing to sodium content of preparations)
  • Max 4.5g every 8 hours if creatinine clearance 20–40mL/minute and 4.5g every 12 hours if creatinine clearance less than 20mL/minute