PILOCARPINE

Miotic with parasympathomimetic action

Dosage Forms

Eye drops

2%
4%

Intracameral injection

0.50%

Uses

  • Chronic open-angle glaucoma
  • Acute angle-closure glaucoma

Dose and Duration

Treatment of chronic open-angle glaucoma

Adult: apply 1–2 drops every 6 hours

Acute angle-closure glaucoma (before surgery)

Adult and child: 1 drop of 2% solution every 10 minutes for 30–60 minutes, then 1 drop every 1–3 hours until intraocular pressure subsides

Contraindications

  • Acute iritis
  • Hypersensitivity
  • Anterior uveitis
  • Acute uveitis
  • Some forms of secondary glaucoma

Side Effects

Systemic side-effects are rare following ocular application. Ocular side effects include:

  • Burning, itching, stinging, pain in the eyes
  • Blurred vision
  • Conjuctival vascular congestion
  • Myopia
  • Vitreous haemorrhage
  • Retinal detachment
  • Pupillary block
  • Headache
  • Brow ache
  • Ciliary spasm
  • Sensitisation of the eye lids
  • Decreases in visual acuity in poor illumination

Patient Instructions

  • Do not exceed the stated dose
  • Discard any remaining solution 28 days since first opening of container
  • In case of blurred vision, do not drive until vision is clear
  • The dropper tip should not touch any surface

Pregnancy

  • Can be used

Breast-feeding

  • Can be used

⚠️ Caution

  • Do not use after angle-closure surgery because of a risk of posterior synechiae forming
  • Ophthalmic pilocarpine may be systemically absorbed
  • Only use in pregnancy and breast-feeding if potential benefit outweighs risk
  • Systemic absorption may occur in patients receiving high doses. Therefore use with caution in patients with bronchial asthma, peptic ulceration, urinary tract obstruction, Parkinson's disease, acute heart failure and hypertension
  • Perform a fundus examination in all patients before starting pilocarpine therapy since retinal detachment has been associated with the use of miotics in susceptible patients and those with existing retinal disease
  • Carry out regular monitoring of visual fields and intra-ocular pressure in patients on long-term therapy