Powder for Injection
300 mg
Dosage Forms
Uses
Dose and Duration
Visceral leishmaniasis (unresponsive to, or intolerant of antimonial compounds)
Adult and child: by deep IM injection or by IV infusion, 4 mg/kg 3 times a week for 5–25 weeks or longer, until consecutive splenic aspirates taken 14 days apart are negative
Cutaneous leishmaniasis (infections caused by L. aethiopica or L. guyanensis)
Adult and child: by deep IM injection or by IV infusion, 3–4 mg/kg once or twice a week until the lesion is no longer visible
Diffuse cutaneous leishmaniasis (infections caused by L. aethiopica)
Adult and child: by deep IM injection or by IV infusion, 3–4 mg/kg once a week, continued for at least 4 months after parasites are no longer detectable in slit-skin smears
Mucocutaneous leishmaniasis unresponsive to antimonial compounds
Adult and child: by deep IM injection or by IV infusion, 4 mg/kg 3 times a week for 5–25 weeks or longer, until lesion is no longer visible
Treatment of pneumocystis carinii pneumonia
Adult and child: by slow IV infusion or by deep IM injection, 4 mg/kg daily for at least 14 days
Prophylaxis of P.carinii pneumonia
Adult and child: 4 mg/kg once every 4 weeks
Treatment of haemolymphatic stage of T. brucei gambiense infection
Adult and child: by IM injection, 4 mg/kg daily or on alternate days for a total of 7–10 doses
Treatment of meningoencephalitic stage of T. brucei gambiense (prior to melarsoprol)
Adult and child: by IM injection, 4 mg/kg daily on day 1 and day 2