OFLOXACIN

Fluoroquinolone antibacterial

Dosage Forms

Tablet

200 mg

Uses

  • Urinary tract infections
  • Acute or chronic prostatitis
  • Lower respiratory tract infections
  • Uncomplicated gonorrhoea
  • Uncomplicated genital chlamydial infection
  • Non-gonococcal urethritis
  • Pelvic inflammatory disease
  • Multi-drug resistant tuberculosis (MDR-TB) (specialist use only)

Dose and Duration

Urinary tract infections

Adult: by mouth, 200–400 mg once daily preferably in the morning. May be increased if necessary in upper urinary tract infections to 400 mg twice daily for 5 days

Acute or chronic prostatitis

Adult: by mouth, 200 mg twice daily for 28 days

Lower respiratory tract infections

Adult: by mouth, 400 mg preferably in the morning for 7 days

Uncomplicated gonorrhoea

Adult: by mouth, 400 mg as a single dose

Uncomplicated genital chlamydial infection, non-gonococcal urethritis

Adult: by mouth, 400 mg daily in single or divided doses for 7 days

Pelvic inflammatory disease

Adult: by mouth, 400 mg twice daily for 14 days

Multi-drug resistant tuberculosis (MDR-TB)

Adult and child: 15-20 mg/kg daily. Maximum 800 mg

Contraindications

  • Hypersensitivity to quinolones
  • Children < 12 years
  • History of tendon damage due to quinolones

Side Effects

  • Nausea, vomiting, diarrhoea
  • Headache, dizziness
  • Hepatic dysfunction
  • Tendon damage
  • Rashes, hypersensitivity

Interactions

  • Ciclosporin (increased concentration of nephrotoxicity)
  • Antacids (reduced absorption of ofloxacin)
  • Warfarin (increased anticoagulant effect)
  • Oral iron (reduced absorption of ofloxacin)
  • Zinc (reduced absorption of ofloxacin)
  • Theophylline(increased risk of convulsions)

Patient Instructions

  • Take at least two hours apart from iron, zinc, milk, dairy products or magnesium trisilicate mixture (antacids)

Pregnancy

  • Do not use

Breast-feeding

  • Do not use

⚠️ Caution

  • Discontinue if psychiatric, neurological or hypersensitivity reactions occur
  • For MDR-TB, ofloxacin can be used in pregnancy, breast-feeding and children as benefits outweigh risks