OCTREOTIDE

Synthetic octapeptide analogue of somatostatin, a naturally occurring inhibitory hormone. It inhibits the secretion of growth hormone, glucagon, insulin, and gastrin.

Dosage Forms

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Solution for injection

50 microgram per 1 ml

Uses

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  • Peptic ulcer
  • carcinoid tumours with features of carcinoid syndrome
  • Acromegaly
  • Gastrointestinal bleeding
  • Vasoactive Intestinal Peptide-secreting tumor (VIPomas), glucagonomas

Dose and Duration

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Upper GI bleeding, carcinoid tumours with features of carcinoid syndrome, VIPomas, glucagonomas

By subcutaneous or intramuscular injection

Adult: Initially 50 micrograms 1–2 times a day, adjusted according to response; increased to 200 micrograms 3 times a day, higher doses may be required exceptionally. Dose may be given by intravenous injection (with ECG monitoring and after dilution)

Acromegaly

By deep intramuscular injection using depot injection

Adult: Initially 20 mg every 4 weeks for 3 months then adjusted according to response, increased if necessary to 30 mg every 4 weeks.

Side Effects

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  • Arrhythmias
  • Hyperbilirubinaemia
  • Hypothyroidism
  • Skin reactions

Contraindications

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  • Pregnancy
  • Severe liver cirrhosis

Interactions

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  • Octreotide decreases the absorption of oral ciclosporin

Pregnancy

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  • Do not use

Breast-feeding

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  • Do not use

⚠️ Caution

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  • Effective contraception required during treatment
  • Dose reduction in liver impairment