Tablet
15 mg
Injection
2.5 mg/ml
Dosage Forms
Uses
Dose and Duration
Myasthenia gravis
Adult and child > 12 years: by mouth,
initially 15–30 mg at suitable intervals throughout the day;
gradually increase until desired response is obtained.
Usual total daily dose, 75–300 mg. Most patients
tolerate max 180 mg
By SC or IM injection: 1–2.5 mg as required up to a total daily dose of 5–20 mg
Child 6–12 years: by mouth, initially 15 mg, gradually increased to a usual total daily dose of 15–90 mg given in divided doses at appropriate intervals
By IM or SC injection: 0.2–0.5 mg as required
Child 1 month–6 years: by mouth, initially
7.5 mg.
By IM or SC injection, 0.2–0.5 mg as
required
Neonate: 1–2 mg by mouth or 0.05–0.25 mg.
By SC or IM injection every 4 hours, 30 minutes
before feeds
Reversal of non-depolarizing block
Adult: by IV injection over 1 minute, 2.5 mg followed by 0.5 mg supplements if required to maximum total dose of 5 mg
Child: 0.04 mg/kg (titrate using peripheral nerve stimulator). Max 2.5 mg
Postoperative urinary retention
Adult: by SC or IM injection, 0.5 mg