MITOMYCIN

Anthracycline anticancer

Dosage Forms

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Powder for injection

20 mg

Uses

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  • Upper gastrointestinal cancer
  • Breast cancer
  • Superficial bladder tumours

Dose and Duration

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All uses

Consult product literature. Usual dose interval is 6 weeks

Contraindications

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  • Hypersensitivity

Side Effects

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  • Myelosuppression; leucopoenia, thrombocytopenia
  • Anorexia, nausea, vomiting
  • Malaise, weight loss
  • Bleeding tendency
  • Anaemia
  • Pulmonary oedema, interstitial pneumonia, pulmonary fibrosis
  • Anaphylaxis
  • Injection site reactions

Interactions

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  • Clozapine: (increased risk of agranulocytosis)

Pregnancy

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  • Do not use

Breast-feeding

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  • Discontinue breastfeeding

Storage

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  • Store for 24 hours in a cool place after reconstitution. Do not refrigerate or freeze

⚠️ Caution

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  • Mitomycin is irritant to tissues. Handle with caution
  • Discontinue treatment immediately if signs such as itching, rash, hot flush, sweating, dyspnoea and decreased blood pressure occur
  • Causes delayed bone marrow toxicity. Prolonged use may result in permanent bone-marrow damage, lung fibrosis and renal damage
  • Avoid simultaneous use of radiotherapy
  • For administration into specific tissues, mitomycin can be given by the intra-arterial route directly into the tumours
  • Because of cumulative myelosuppression, patients should be fully re-evaluated after each course and the dose reduced if the patient has experienced any toxic effects
  • If disease progression continues after two treatment courses, stop drug as chances of response are minimal
  • Anticancer medicines should only be handled by health workers trained and experienced in cytotoxic medicines