METOCLOPRAMIDE

Antiemetic, Prokinetic. It is effective against nausea and vomiting associated with gastrointestinal disorders, migraine, after surgery, chemotherapy and radiotherapy

Dosage Forms

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Tablet

10 mg

Injection

5 mg/ml

Uses

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  • Nausea and vomiting

Dose and Duration

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Nausea and vomiting

Adult: 10 mg every 8 hours for 5 days by mouth, IV or IM injection

Child 15-19 years and weight > 60 kg: 10 mg every 8 hours only in chemotherapy-induced nausea

Child 15-19 years and weight < 60 kg: 5 mg every 8 hours only in chemotherapy-induced nausea

Contraindications

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  • Gastrointestinal obstruction, perforation, haemorrhage
  • Three to four days after gastrointestinal surgery
  • Children

Side Effects

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  • Extrapyramidal side effects especially in children and young adults
  • Prolonged treatment may cause tardive dyskinesia (rhythmic, involuntary movements of tongue and face)

Interactions

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  • Ciclosporin: (increased concentration of ciclosporin)

Patient Instructions

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  • Stop taking medicine if you experience tremors, restlessness, abnormal face and body movements

Pregnancy

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  • Can be used

Breast-feeding

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  • Do not use

⚠️ Caution

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  • Withdraw medicine immediately in case extrapyramidal symptoms occur
  • Dose intervals should be at least 6 hours apart even if the previous dose is vomited
  • Avoid giving for longer than 5 days
  • Give with caution in patients with underlying neurological conditions and those treated with other centrally-acting medicines
  • Metoclopramide may worsen Parkinson’s disease