Powder for reconstitution for injection
500 mg
Dosage Forms
Uses
Dose and Duration
Aerobic and anaerobic Gram-positive and Gram-negative
infections, hospital-acquired septicaemia
By IV injection over 5 minutes or by IV infusion
Adult and child > 12 years or 50 kg: 0.5–1 g every 8 hours
Child 3 months–12 years or <50 kg: 10–20 mg/kg every 8 hours
Neonate 7–28 days: 20 mg/kg every 8 hours. Double dose in severe infection
Neonate under 7 days: 20 mg/kg every 12 hours. Double dose in severe infection
In renal impairmentGive dose as in table below
| eGFR (ml/minute/1.73 m²) | Dose |
|---|---|
| 26–50 | Normal dose every 12 hours |
| 10–25 | ½ normal dose every 12 hours |
| <10 | ½ normal dose every 24 hours |
Bronchopulmonary infection in cystic fibrosis, meningitis
By IV infusion,
Adult and child over 12 years or 50 kg: 2 g every 8 hours
Child 1 month–12 years or <50 kg: 40 mg/kg every 8 hours
Neonate 7–28 days: 40 mg/kg every 8 hours
Neonate under 7 days: 40 mg/kg every 12 hours
Endocarditis (in combination with another antibacterial)
Adult over 18 year: 2 g every 8 hours