MEDROXYPROGESTERONE ACETATE

Long-acting, injectable, progestogen-only contraceptive

Dosage Forms

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Aqueous suspension for injection

150 mg/ml

Uses

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  • Long-term (3 months) prevention of unwanted pregnancy

Dose and Duration

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Prevention of unwanted pregnancy

1 injection every 12 weeks (3 months) during the first 5 days of a normal menstrual cycle or 5 days post-partum if the mother is not breast-feeding

Initiation as for etonogestrel implant

Use for as long as contraception is desired

Contraindications

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  • Breast cancer
  • Uncontrolled high blood pressure
  • Deep vein thrombosis
  • Recent stroke
  • Uncontrolled diabetes
  • Severe or recent liver disease
  • Unexplained abnormal vaginal bleeding

Side Effects

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  • Menstrual disturbances
  • Delayed return to fertility after stopping the injection
  • Nausea, vomiting
  • Allergic reactions
  • Weight gain
  • Osteoporosis

Patient Instructions

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  • Return of fertility can be delayed after stopping use

Pregnancy

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  • Do not use

Breast-feeding

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  • Can be used

⚠️ Caution

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  • Shake vial before use to mix the suspension well
  • Medroxyprogesterone is a good alternative to oral contraceptives in patients on rifampicin, carbamazepine, isoniazid, and phenobarbital as these medicines do not affect the contraceptive effectiveness
  • Commonly known as Depo-Provera®