Tablet
100 mg
Dosage Forms
Uses
Dose and Duration
Monotherapy of seizures
Adult and child over 12 years: initially 25 mg once daily for 14 days, increased to 50 mg once daily for 14 days, and then increased every 7–14 days by no more than 100 mg.
Usual maintenance dose 100–200 mg daily in 1–2 divided doses (up to 500 mg daily)
Monotherapy of typical absence seizures
Child 2–12 year: initially 0.3 mg/kg daily in 1–2 divided doses for 14 days then 0.6 mg/kg daily in 1–2 divided doses for further 14 days, thereafter increased by max 0.6 mg/kg every 7–14 days.
Usual maintenance 1–10 mg/kg daily in 1–2 divided doses (max 15 mg/kg)
Adjunctive therapy of seizures with valproate
Adult and child over 12 years: initially 25 mg on alternate days for 14 days then 25 mg once daily for more 14 days, thereafter increased by max 50 mg every 7–14 days.
Usual maintenance, 100–200 mg daily in 1–2 divided doses
Child 2–12 years: initially 0.15 mg/kg once daily for 14 days (give 2 mg on alternate days if body weight is below 13 kg) then 0.3 mg/kg once daily for further 14 days, thereafter increased by max 0.3 mg/kg every 7–14 days.
Usual maintenance 1–5 mg/kg daily in 1–2 divided doses (max 200 mg daily in 2 divided doses)
Adjunctive therapy of seizures (with enzyme inducing drugs)
without valproate
Adult and child over 12 years: initially 50 mg once daily for 14 days then 50 mg every 12 hours for more 14 days, thereafter increased by max 100 mg every 7–14 days.
Usual maintenance 100–200 mg every 12 hours (up to 700 mg daily has been required)
Child 2–12 years: initially 0.3 mg/kg every 12 hours for 14 days then 0.6 mg/kg every 12 hours for more 14 days, thereafter increased by max 1.2 mg/kg every 7–14 days.
Usual maintenance dose 2.5–7.5 mg/kg every 12 hours (max 200 mg every 12 hours)
Adjunctive therapy of seizures (without enzyme inducing drugs)
without valproate
Adult and child over 12 years: same as in monotherapy for seizures above
Child 2–12 years: same as above in monotherapy of typical absence seizures. Max 200 mg daily
Monotherapy or adjunctive therapy of bipolar disorder (without
enzyme inducing drugs) without valproate
Adult over 18 years: initially 25 mg once daily for 14 days, then 50 mg daily in 1–2 divided doses for further 14 days, then 100 mg daily in 1–2 divided doses for further 7 days.
Usual maintenance 200 mg daily in 1–2 divided doses (max 400 mg daily)
Adjunctive therapy of bipolar disorder with valproate
Adult over 18 years: initially 25 mg on alternate days for 14 days, then 25 mg once daily for further 14 days, then 50 mg daily in 1–2 divided doses for further 7 days.
Usual maintenance 100 mg daily in 1–2 divided doses (max 200 mg daily)
Adjunctive therapy of bipolar disorder (with enzyme inducing
drugs) without valproate
Adult over 18 years: initially 50 mg once daily for 14 days, then 50 mg every 12 hours for further 14 days, then 100 mg every 12 hours for further 7 days, then 150 mg every 12 hours for further 7 days.
Usual maintenance 200 mg every 12 hours