Solution for injection
50 mg/ml
Dosage Forms
Uses
Dose and Duration
Induction and maintenance of anaesthesia and analgesia in short
procedures
Adult and child over 12 years:
by IM injection
6.5–13 mg/kg adjusted according to response (10mg/kg produces
12–25 minutes of surgical anaesthesia); maintenance, 50–100% of
induction dose as required
In diagnostic and procedures not involving intense pain, use 4 mg/kg
By IV injection over at least 1 minute, 1–4.5 mg/kg adjusted according to response (2 mg/kg usually produces 5–10 minutes of surgical anaesthesia); maintenance, 50–100% of induction dose as required
Neonate and child up to 12 years:
by IV injection
over at least 60 seconds, 1–2 mg/kg produces 5–10 minutes of
surgical anaesthesia, adjusted according to response
Induction and maintenance of anaesthesia and analgesia: longer
procedures
Adult and child over 12 years:
by IV infusion
with solution containing 1 mg/ml in dextrose 5% or normal
saline, total induction dose 0.5–2 mg/kg; maintenance (using
microdrip infusion) 0.01 0.045 mg/kg/minute, rate adjusted
according to response
Child up to 18 years:
0.5–2 mg/kg by IV injection, fol lowed by continuous IV infusion
of 0.01–0.045 mg/kg /minute adjusted according to response
Neonate:
0.5–2 mg/kg by IV injection, followed by continuous IV infusion
of 0.008 mg/kg /minute adjusted according to response. In deep
anaesthesia, up to 0.03 mg/kg/minute may be used
Sedation prior to invasive or painful procedures
Child 1 month–18 years:
1–2 mg/kg as a single dose