HYOSCINE BUTYLBROMIDE

Antimuscarinic agent that reduces gastrointestinal motility

Dosage Forms

Solution for injection

20 mg/ml

Uses

  • Spasm of gastrointestinal or genito-urinary disorders
  • Diagnostic agent and antispasmodic in radiology
  • Bowel colic
  • Excessive respiratory secretions

Dose and Duration

Bowel colic and excessive respiratory secretions in palliative care
  • Adult: by SC infusion, 20 mg every 4 hours but may be given hourly in excessive respiratory secretions (max 300 mg in bowel colic and 120 mg for excessive respiratory secretions in 24 hours)
  • Child > 12 years: by IM or IV injection, 10–20 mg 3–4 times daily
  • Child 5–12 years: by IM or IV injection, 5–10mg 3–4 times daily
  • Child 1 month–4 years: by IM or IV injection, 0.3–0.5 mg/kg (max 5 mg) 3–4 times daily
Acute spasm and spasm in diagnostic procedures

Given by IM or slow IV injection over 1 minute

  • Adult and child over 12 years: 20 mg repeated after 30 minutes if necessary (may be repeated more frequently in endoscopy). Maximum daily dose of 100 mg
  • Child 2–6 years: 5 mg repeated after 30 minutes if necessary (may be repeated more frequently in endoscopy). Maximum daily dose of 15 mg daily
  • Child 6–12 years: 5–10 mg repeated after 30 minutes if necessary (may be repeated more frequently in endoscopy). Maximum daily dose 30 mg daily

Preparation

  • Solution for IV injection may be diluted with Glucose 5% or Sodium Chloride 0.9%

Contraindications

  • Myasthenia gravis
  • Paralytic ileus
  • Pyloric stenosis
  • Toxic megacolon
  • Angle-closure glaucoma
  • IM injection in patients treated with anticoagulants

Side Effects

  • Anaphylactic reactions
  • Visual disturbances
  • Tachycardia
  • Dizziness
  • Dry mouth, constipation
  • Injection site reactions
  • Hypersensitivity to hyoscine

Patient Instructions

  • Consult your ophthalmologist immediately in case you develop a red eye with loss of vision after injection with hyoscine

Pregnancy

  • Do not use

Breast-feeding

  • Can be used

⚠️ Caution

  • Use with caution in thyrotoxicosis, cardiac insufficiency or failure, in cardiac surgery since it may further accelerate heart rate, pyrexia, autonomic neuropathy, intestinal and urinary outlet obstruction and hypertension
  • May cause elevation of intraocular pressure in patients with undiagnosed and untreated angle-closure glaucoma