GOSERELIN

Gonadotropin releasing hormone super-agonist (GnRH)

Dosage Forms

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Implant

3.6 mg

Uses

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  • Prostate cancer
  • Advanced breast cancer
  • Endometriosis
  • Endometrial thinning
  • Uterine fibroids
  • Assisted reproduction

Dose and Duration

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All indications
One 3.6 mg capsule injected subcutaneously into the anterior abdominal wall every 28 days.
Endometriosis
Use for 6 months.
Endometrial thinning
Give for 4−8 months.

Contraindications

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  • Children
  • Undiagnosed vaginal bleeding
  • Hypersensitivity to goserelin

Side Effects

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  • Pain, hematoma, haemorrhage at injection site
  • Ureteric obstruction in men
  • Spinal cord compression in men
  • Depression, mood changes
  • Impaired glucose tolerance, weight gain
  • Decreased libido, erectile dysfunction
  • Paraesthesia
  • Cardiac and myocardial infarction
  • Hot flush
  • Rash
  • Alopecia, gynaecomastia
  • Bone pain

Interactions

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  • Antiarrhytmic medicines (increased risk of QT interval prolongation)

Pregnancy

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  • Do not use

Breast-feeding

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  • Do not use

⚠️ Caution

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  • Monitor patient closely for depression