Brucellosis (in combination with doxycycline)
Adult: 5–7 mg/kg IV once daily for 14 days
Child <8 years: 7.5 mg/kg daily in 1–3
divided doses for 14 days
Neonatal meningitis, neonatal sepsis (in combination with
ampicillin or benzylpenicillin)
2.5 mg/kg IV every 12 hours for 21 days
Plague
1.7 mg/kg IV or IM every 8 hours for 7 days
Septicaemia (in combination with cloxacillin or ceftriaxone or
benzylpenicillin or chloramphenicol)
Adult: 1.5–2 mg/kg IV or IM every 8 hours for
14 days
Child: 3.5–4 mg/kg IV every 8 hours for 14 days
Neonate: 3.5–4 mg/kg every 8–12 hours for 14
days
Severe pneumonia, endocarditis (first line treatment; in
combination with ampicillin)
Adult: 5–7 mg/kg IV daily in 1–2 divided doses
for 5 days
Child >7 days: 2.5 mg/kg IV every 8 hours for
5–10 days
Child <7 days: 2.5 mg/kg IV every 12 hours
for 5–10 days
In moderate pneumonia, give for 7 days
In very severe pneumonia, give for 10 days
Surgical prophylaxis
Adult: 1.5 mg/kg by slow IV injection over 3
minutes, at least 30 minutes before procedure
Acute kidney infection
Adult: 5–7 mg/kg IV daily in 2–3 doses
Child: 2.5 mg/kg every 8 hours for 7 days
Eye or ear infection
Apply 1 drop every 2 hours, and then reduce frequency as
infection is controlled. Continue for up to 48 hours after
healing is complete.
In severe infection, apply 1 drop every hour.