Powder for Injection
500 mg
Dosage Forms
Uses
Dose and Duration
Treatment of CMV infection
Adult and child: by IV infusion over 1 hour, induce with 5
mg/kg every 12 hours for 14–21 days. In patients at risk of
relapse CMV retinitis, give a maintenance dose of 6 mg/kg once
daily on 5 days per week or 5 mg/kg once daily until adequate
recovery of immunity
Prevention of CMV
Adult and child: induce with 5 mg/kg by IV infusion every 12
hours for 7–14 days and maintenance dose as above in treatment
Congenital cytomegalovirus infection of the CNS
Neonate: by IV infusion, 6 mg/kg every 12 hours for 6 weeks
In renal impairment:
| Creatinine clearance | Induction dose |
|---|---|
| ≥ 70 ml/min | 5 mg/kg every 12 hours |
| 50–69 ml/min | 2.5 mg/kg every 12 hours |
| 25–49 ml/min | 2.5 mg/kg/day |
| 10–24 ml/min | 1.25 mg/kg/day |
| < 10 ml/min | 1.25 mg/kg/day after haemodialysis |