Treatment of folate-deficient (megaloblastic) anaemia (during
severe malnutrition, repeated malaria attacks, intestinal
parasite infestations, pregnancy)
Prevention of anaemia in sickle-cell anaemia
Prevention of spinal cord defects in foetus
Dose and Duration
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Treatment and prevention of anaemia
Adult and child >5 years: 5 mg once daily for 4 months
Child <5 year: 2.5 mg once daily for 4 months
Prevention of spinal cord defects in foetus
Adult: 5 mg once daily throughout pregnancy
Interactions
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Sulfadoxine + pyrimethamine (cancelled effect)
Co-trimoxazole (cancelled effect)
Patient Instructions
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Compliance is very important for pregnant women as anaemia can
affect the proper development of the baby and lead to poor health
or death of the mother
When given with sulfadoxine + pyrimethamine (SP) for IPTp, delay
folic acid for 1 week after taking SP
Pregnancy
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Can be used
Breast-feeding
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Can be used
⚠️ Caution
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In megaloblastic anaemias, folic acid should be given with
vitamin B₁₂