Anaesthesia and clinical procedures
By IV injection
Adult: 0.2 mg over 15 seconds, then 0.1 mg at 60 second intervals if required. Usual dose range, 0.3–0.6 mg (maximum total dose, 1 mg)
Child 1 month–18 years: 0.01 mg/kg (max 0.2 mg). Repeated at 1 minute intervals if required. Maximum total dose of 0.05 mg/kg
Neonate: 0.001 mg/kg repeated at 1 minute intervals if required
If drowsiness recurs after injection, by IV infusion,
Child 1 month–18 years: 0.002- 0.01 mg/kg/hour, adjusted according to response. Maximum dose 0.4 mg/hour
Neonate: 0.002- 0.01 mg/kg/hour, adjusted according to response
Intensive care
Adult: by IV injection, 0.3 mg over 15 seconds, then 0.1 mg at 60 second intervals if required (maximum total dose 2 mg) if drowsiness recurs either, by IV injection, 0.3 mg; or by IV infusion of 0.1–0.4 mg/hour adjusted according to response
Child and neonate: dose same as for anaesthesia