Injection
10 mg/ml
Dosage Forms
Uses
Dose and Duration
Cryptococcal meningitis and systemic candidosis (in combination
with Amphotericin B in severe cases)
Adult and child: by IV infusion over 20–40 minutes, 50 mg/kg every 6 hours for up to 7 days (at least 4 months in cryptococcal meningitis). In extremely sensitive organisms, use half dose
By mouth, 50–150 mg/kg daily in divided doses
Note: In renal impairment, increase dosing intervals
Moderate renal impairment: 50 mg/kg every 24 hours
Mild renal impairment: 50 mg/kg every 12 hours
Severe renal impairment: initially 50 mg/kg, then adjust subsequent doses based on serum concentration of flucytosine to maintain plasma levels of 20–50 micrograms/ml