FLUCLOXACILLIN

A narrow spectrum beta-lactamase stable penicillin. Flucloxacillin has activity against beta-lactamase producing Gram-positive bacteria but not against Methicillin-resistant Staphylococcus aureus (MRSA)

Dosage Forms

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Powder for Reconstitution for Injection

250 mg powder for solution for injection
500mg powder for solution for injection vials

Oral solution

25 mg per 1ml
50 mg per 1ml

Capsule

250 mg
500 mg

Uses

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  • Impetigo
  • Cellulitis and Erysipelas
  • Diabetic foot
  • Endocarditis
  • Osteomyelitis

Dose and Duration

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Mixed infections involving beta-lactamase producing Staphylococci

By Mouth

Child 1 month – 1 year: : 62.5–125mg 4 times a day
Child 2 – 9 years: : 125–250mg 4 times a day
Child 10 – 17 years: : 250–500mg 4 times a day
Adult: 250–500mg 4 times a day

By injection

Adult: 250–500mg every 6 hours

By slow intravenous injection or infusion

Adult: 0.25–2g every 6 hours

Contraindications

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  • Hypersensitivity to penicillins
  • History of flucloxacillin-associated jaundice or hepatic dysfunction. Cholestatic jaundice and hepatitis may occur very rarely, up to two months after treatment with flucloxacillin has been stopped

Side Effects

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  • Skin rash, urticaria, fever, pruritus, joint pain
  • Angioedema, anaphylaxis
  • Diarrhoea, nausea, vomiting
  • Stevens-Johnson syndrome
  • Eosinophilia

Pregnancy

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  • Can be used

Breast-feeding

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  • Can be used

⚠️ Caution

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  • Use with caution in patients with porphyria and in newborns
  • Avoid contact with skin due to risk of skin sensitisation
  • In renal imparement - accumulation of sodium from injection can occur in patients with renal failure.
  • With intravenous use High doses may cause nephrotoxicity or neurotoxicity.