Hypertension stage 2 (with another antihypertensive)
Adult: 5 mg once daily. Usual maintenance dose
20 mg once daily (max 40 mg once daily)
Child 12–18 years: 2.5 mg once daily. Usual
maintenance dose 10–20 mg daily in 1–2 divided doses (max 40 mg
daily in 1–2 divided doses if body-weight over 50 kg)
Child 1 month–12 years: 0.1 mg/kg once daily,
increased as needed to max 1 mg/kg daily in 1–2 divided doses
Neonate: 0.01 mg/kg once daily increased as
necessary up to 0.5 mg/kg daily in 1–3 divided doses
Renal failure: 2.5 mg once daily if eGFR is
<30 ml/minute/1.73 m²
Heart failure
Adult: 2.5 mg once daily under close medical
supervision increased gradually over 2–4 weeks to 10–20 mg, once
or twice daily if tolerated (max 40 mg)