DOMPERIDONE

Dopamine receptor antagonist which stimulates gastric emptying and small intestinal transit, and enhances the strength of oesophageal sphincter contraction to stop emesis.

Dosage Forms

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Tablet

10 mg

Suspension

5 mg/5 ml

Uses

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  • Nausea and vomiting
  • Dyspepsia
  • Gastro-oesophageal reflux

Dose and Duration

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All uses
Adult and child over 12 years and body weight >35 kg: by mouth, 10 mg every 6–8 hours (max 40 mg daily)
Child with body weight up to 35 kg: 0.25–0.5 mg/kg eve ry 6–8 hours (max 1.0 mg/kg daily) Do not use for more than 7 days

Contraindications

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  • Prolactinoma
  • In case increased gastrointestinal motility is harmful

Side Effects

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  • Bloating
  • Skin rash, itching
  • Ventricular arrhythmias, Torsades de pointes

Interactions

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  • Erythromycin (increased plasma concentration of domperidone)

Patient Instructions

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  • Take your medicine at least 30 minutes before a meal or 2 hours after a meal
  • Do not crush tablets
  • Seek medical attention in case palpitations or fainting

Pregnancy

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  • Do not use

Breastfeeding

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  • Can be used

⚠️ Caution

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  • Use with caution in patients with QT-interval prolongation, concomitant use with drugs that prolong the QT interval, electrolyte imbalances, cardiac disease, patients over 60 years of age, children or oral dose >30 mg daily
  • Avoid use of domperidone in patients with hepatic impairment. Reduce dose in renal impairment