DEXAMETHASONE + TOBRAMYCIN

Anti-inflammatory and anti-infective medicine

Dosage Forms

▼

Eye drops

dexamethasone 0.1% + tobramycin 0.3%

Uses

▼
  • Treatment of inflammation and prevention of infection associated with cataract surgery

Dose and Duration

▼
Treatment of inflammation and prevention of infection associated with cataract surgery
Adult and child ≥ 2 years:0. instil 1 drop in the eyes every 4–6 hours while patient is awake for 14 days (max 24 days). Dosage may be increased to 1 drop every 2 hours while patient is awake during the first 24–48 hours.

Decrease dosing frequency gradually with improvement

Contraindications

▼
  • Herpes simplex keratitis and other viral eye diseases
  • Fungal disease of the eye
  • Mycobacterial infections of the eye
  • Untreated purulent infections
  • Hypersensitivity to dexamethasone or tobramycin

Side Effects

▼
  • Nausea, dyspepsia
  • Hypersensitivity reactions
  • Irritation at injection site
  • Inhibition of growth in children ( on long term use)
  • Cushing syndrome (on long term use)
  • Stinging, burning, redness, watering of eyes and increased intraocular pressure (longer than 2 weeks treatment) in ocular application

Interactions

▼
  • Live vaccines (no effect of vaccines due to impaired immune response)
  • Insulin (reduced effect of insulin)
  • Amphotericin B (increased risk of hypokalaemia)
  • Carbamazepine, rifampicin, phenytoin, phenobarbital (reduced effect of dexamethasone)
  • Lopinavir (reduced concentration of lopinavir)
  • Methotrexate (increased risk of blood disorders)

Patient Instructions

▼
  • Do not use this medication for more than 1 week unless you have consulted your ophthalmologist
  • Do not wear contact lenses during the treatment period
  • In case of transient blurring of vision, do not operate hazardous machinery or drive until vision is clear
  • Keep bottle tightly closed. Do not let the dropper tip touch any surface to minimise risk of infection

Pregnancy

▼
  • Can be used

Breastfeeding

▼
  • Can be used

⚠️ Caution

▼
  • Use with caution in patients with glaucoma or a family history of glaucoma
  • Do not use for longer than 1 week unless under ophthalmic supervision; prolonged use may lead to a rise in intraocular pressure and secondary ocular infections