CLOXACILLIN

Penicillin antibacterial with good activity against Gram positive bacteria for example Staphylococcus aureus. It is not inactivated by penicillinases produced by S. Aureus.

Dosage Forms

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Powder for injection

500 mg

Capsules

250 mg

Uses

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  • Severe bacterial infections
  • Septicaemia
  • Septic arthritis
  • Severe pneumonia due to Staphylococcus aureus
  • Pyomyositis
  • Osteomyelitis
  • Endocarditis due to Staphylococcus aureus
  • Pneumonia
  • Infected skin wounds
  • Boils

Dose and Duration

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Severe bacterial infections (in combination with gentamicin)
Adult:1–2 g IV every 4–6 hours for 2–3 weeks
Child > 2 years: 50 mg/kg every 4–6 hours
Child < 2 years: 25 mg/kg every 4–6 hours
Boils, infected skin wounds
Adult:500 mg PO every 6 hours for 5–10 days
child:125‒250 mg every 6 hours for 5–10 days

Contraindications

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  • Penicillin allergy
  • Cephalosporin allergy (cross-sensitivity may occur)

Side Effects

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  • Stomach upset
  • Allergic reaction (skin rash)
  • Liver damage

Interactions

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  • Methotrexate (increased risk of methotrexate toxicity)

Patient Instructions

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  • Take at least 30 minutes before food

Pregnancy

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  • Can be used

Breastfeeding

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  • Can be used

⚠️ Caution

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  • Use cautiously in patients with history of liver disease and elderly. Avoid giving for durations longer than 2 weeks