Tablet
25 mg
Capsules
100 mg
Concentrate for intravenous infusion
50mg/ml
Dosage Forms
Uses
Dose and Duration
Adjust dose according to plasma ciclosporin concentration and renal function. Lower doses are required when ciclosporin is used with other immunosuppressants
Organ transplantation
Adult and child over 3 months:
by mouth, 10–15 mg/kg 4–12 hours before surgery given
in 2 divided doses, then 10–15 mg/kg in 2 divided doses for 1–2
weeks and reducing it gradually to a maintenance dose of 2–6
mg/kg daily in 2 divided doses
By IV infusion: if using concentrated solution, give 1/3rd of the corresponding dose by mouth over 2–6 hours. Same dose as for oral administration when diluted
Bone marrow transplantation, graft-versus-host disease
Adult and child over 3 months:by mouth, 12.5–15 mg/kg daily in 2 divided doses for 2
weeks, starting on the day before surgery, followed by 12.5
mg/kg daily in 2 divided doses for 3–6 months, then gradually
reduced to zero by 1 year after transplantation.
By IV infusion over 2–6 hours, 3–5 mg/kg daily for 2 weeks, starting on the day before surgery, followed by maintenance doses by mouth
Intractable hiccups
Adult:25–50 mg every 6–8 hours
Nephrotic syndrome
Adult:by mouth, initially 2.5 mg/kg every 12
hours slowly reduced to lowest effective dose according to
proteinuria and serum creatinine measurements. Discontinue after
3 months if no improvement is observed (after 6 months in
membranous glomerulonephritis)
Child:by mouth, initially 3 mg/kg every 12
hours and titrated as in the adult
Inflammatory bowel disease
Adult:by continuous IV infusion, 2 mg/kg daily
over 24 hours adjusted according to blood ciclosporin
concentration and response
Rheumatoid arthritis
Adult: 1.5 mg/kg every 12 hours for 6 weeks
increased gradually according to response and tolerability up to
a maximum 2.5 mg/kg every 12 hours for 6 more weeks
Psoriasis, atopic dermatitis
Adult: initially 1.25 mg/kg (2.5 mg/kg if rapid
improvement is needed) every 12 hours gradually increased if
there is no improvement after 1 month (2 weeks in dermatitis) to
a maximum dose of 2.5 mg/kg every 12 hours. Treat for 8 weeks to
1 year in dermatitis Discontinue if there is no improvement
after 6 weeks of treatment in psoriasis