CHLORPROMAZINE

Sedative antipsychotic medicine

Dosage Forms

Tablet

100 mg
25 mg

Injection

25 mg/ml

Uses

  • Mania, delirium
  • Control spasms in tetanus
  • Excessive vomiting in pregnancy
  • Intractable hiccups
  • Migraine

Dose and Duration

Mania, delirium
Adult: initially, 100–200 mg every 8 hours, then adjust according to response. Daily doses up to 300 mg may be given as a single dose at night
Control spasms in tetanus (alternating with diazepam)
Adult:100 mg every 4–6 hours by nasogastric tube
Child:12.5–25 mg every 4–6 hours by nasogastric tube. Continue for as long as spasms or rigidity persists
Intractable hiccups
Adult:25–50 mg every 6–8 hours
Excessive vomiting in pregnancy
Adult:25 mg repeated as needed (at most every 4 hours). If severe, give by deep IM injection every 6 hours or as required

Contraindications

  • Delirium tremens (uncontrolled shaking in acute alcohol withdrawal)
  • Parkinson's disease
  • Severe liver disease
  • Severe kidney disease

Side Effects

  • Drowsiness, apathy, nightmares, dizziness, insomnia, headache
  • Confusion, depression
  • Extra-pyramidal side effects
  • Uncontrolled shaking

Interactions

  • Alcohol (increased sedation)
  • Diazepam (increased sedation)
  • Phenobarbital (increased sedation)
  • Chlorpheniramine (increased sedation)

Patient instructions

  • Do not take alcohol
  • Do not drive or operate machinery while on treatment

Pregnancy

  • Do not use in 3rd trimester

Breastfeeding

  • Do not use

⚠️ Caution

  • Reduce dose to half or third in elderly patients
  • Avoid abrupt withdrawal (may cause withdrawal symptoms)
  • Health workers should avoid direct contact with chlorpromazine. Do not touch or crush the tablets, and handle injectable solutions with care.
  • Do not initiate treatment for mania and delirium; refer patient to be seen by a specialist. Only give refill doses
  • Benzhexol is used to treat extra-pyramidal side effects of chlorpromazine