Tablet
500 mg
Oral Suspension
125 mg/ml
Powder for solution for injection
750 mg
Dosage Forms
Uses
Dose and Duration
All infections
Treat for 5–10 days. Treatment may be extended to 14 21 days in some severe cases
Adult and child above 12 years: 250 mg every 12
hours (500 mg every 12 hours in more severe lower respiratory
tract infections or if pneumonia suspected)
Child 2–12 years: 15 mg/kg (max 250 mg) every
12 hours
Child 3 months–2 years: 10 mg/kg (max 125 mg)
every 12 hours
Pre- and post-surgery prophylaxis
Give by deep IM or IV injection (over 3–5 minutes) or infusion (over 30 to 60 minutes). In neonates or for doses above 750 mg, use IV route only
Adult:1.5 g by IV injection up to 30 minutes
before the procedure. 3 more doses of 750 mg IM or IV may be
given every 8 hours for high-risk procedures
Child: 50–100 mg/kg daily in 1 or 2 divided
doses for 10 days
Child 1month - 18 years: 50 mg/kg (max 1500 mg)
up to 30 minutes before the procedure. 3 more doses of 30 mg/kg
(max 750 mg) may be given by IM or IV injection every 8 hours
for high-risk procedures
Severe infections
Adult:750 mg every 6–8 hours ( max 1500 mg)
Child 1 month - 18 years: 20 mg/kg (max 750 mg)
every 8 hours
Neonate 21 -28 days: 25 mg/kg every 6 hours
Neonate 7 -21 days: 25 mg/kg every 8 hours
Neonate <7 days: 25 mg/kg every 12 hours
Double the dose in very severe infections
Note: In renal failure, increase dosing interval to every 12 hours; in severe renal failure, give once daily