Drug Information | Vaseguide-lines

Dosage Forms

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Powder for solution for injection

500 mg

1g

2g

Uses

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Respiratory tract infections
Urinary tract infections
Otitis media
Skin and soft-tissue infections
Pre- and post-surgery prophylaxis

Dose and Duration

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All infections

By deep intramuscular injection or by intravenous infusion

Adult: 1–2g every 8–12 hours

Pre- and post-surgery prophylaxis

Deep IM or IV

Adult:1g,single dose to be administered up to 30 minutes before procedure.

Contraindications

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Allergy to cephalosporin
History of severe hypersensitivity to other beta-lactam antibacterial agents

Side Effects

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Thrombophlebitis
Thrombocytosis
Antibiotic associated olitis and fungal infection

Interactions

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Warfarin (possibly enhanced anticoagulant effect)

Pregnancy

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Can be used

Breastfeeding

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Can be used

Directions for administration

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Intramuscular administration used when intravenous administration not possible;single doses over 1g by intravenous route only
With intravenous use, give intermittently or via drip tubing in Glucose 5% or 10% or Sodium chloride 0.9%. Dissolve 2g initially in 10mL(3g in 15mL)infusion fluid, dilute further up to a concentration of 40mg/mL. Give over up to 30 minutes.

⚠️ Caution

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Reduce dose in severe renal impairment.
Use with caution in patients with non-severe hypersensitivity to penicillins and other beta-lactam agents
Prolonged use may result in the overgrowth of other non susceptible microorganisms like enterococci and clostridium difficile, which may require interruption of treatment