CARBIMAZOLE

Adult: 20–60 mg daily in 2–3 divided doses until patient becomes euthyroid. Then reduce dose gradually to a maintenance dose of 5–15 mg once daily for 6–18 months

Or Blocking-replacement regimen: : maintain dose at 20 60 mg daily after patient is euthyroid and add L-thyroxine to the regimen. Therapy is given for 12–18 months

Child 12-18 years: 30 mg daily in single or divided doses until euthyroid then gradually reduce the dose to a maintenance dose of 9–18 mg daily in single or divided doses for 12–24 months

Neonate and child up to 12 years: 0.75 mg/kg daily in single or divided doses until euthyroid (max 1 mg/kg daily in neonate and 30 mg daily in child). Then gradually re duce the dose to a maintenance dose of 0.225–0.45 mg/kg daily in single or divided doses for 12–24 months