ARTESUNATE + AMODIAQUINE

Artemisinin combination therapy antimalarial. First line alternative for uncomplicated malaria

Dosage Forms

Tablet

50 mg artesunate + 153 mg amodiaquine

Uses

  • Uncomplicated malaria

Dose and Duration

Uncomplicated malaria (First line alternative to artemether + lumefantrine)

Take once daily as in table below

Dosage of artesunate tablets
Age Day 1 Day 2 Day 3
5-11 months 25 mg (=½ tab) 25 mg (=½ tab) 25 mg (=½ tab)
1-6 years 50 mg (=1 tab) 50 mg (=1 tab) 50 mg (=1 tab)
7-13 years 100 mg (=2 tabs) 100 mg (=2 tabs) 100 mg (=2 tabs)
> 13 years 200 mg (=4 tabs) 200 mg (=4 tabs) 200 mg (=4 tabs)
Dosage of amodiaquine
Age Day 1 Day 2 Day 3
5-11 months 76 mg (=1/2 tab) 76 mg (=1/2 tab) 76 mg (=1/2 tab)
1-6 years 153 mg (=1 tab) 153 mg (=1 tab) 153 mg (=1 tab)
7-13 years 306 mg (=2 tabs) 612 mg (=4 tabs) 306 mg (=2 tabs) 612 mg (=4 tabs) 306 mg (=2 tabs) 612 mg (=4 tabs)
> 13 years 612 mg (=4 tabs) 612 mg (=4 tabs) 612 mg (=4 tabs)

Contraindications

  • Liver disease

Side Effects

  • Stomach upset
  • Headache and dizziness
  • Itching
  • Liver damage
  • Blood disorders (low white blood cell count)

Patient Instructions

  • Take plenty of fluids during treatment

Pregnancy

  • Do not use in 1st trimester

Breastfeeding

  • Can be used

⚠️ Caution

  • Monitor for jaundice and fever, mouth ulcers or tonsillitis that may develop during treatment
  • Discontinue treatment if the above symptoms occur