Amoxicillin + Clavulanic Acid

Dosage Forms

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250 mg of amoxicillin + 125 mg of clavulanic acid

500 mg of amoxicillin + 125 mg of clavulanic acid

(amoxicillin 200 mg + clavulanic acid 28.5 mg)/5 ml

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All uses

Adult and child > 12 years: 375 mg every 8 hours (500 mg/125 mg every 8 hours in severe infection) for 5–14 days

Child 6–12 years: 250 mg/125 mg every 12 hours or 500 mg/125 mg every 12 hours in severe infections

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Hypersensitivity to penicillins
History of severe hypersensitivity to other beta-lactams
History of jaundice or hepatic dysfunction associated with penicillin- or amoxicillin- with clavulanic acid

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In renal impairment, there is a risk of crystalluria and convulsions with high doses of amoxicillin+ clavulanic acid (particularly during parenteral therapy). Reduce dose if creatinine clearance is less than 30 ml/minute
Maintain adequate hydration with high doses to reduce risk of crystalluria
Monitor liver function in liver disease
Risk of cholestatic jaundice is more common in male patients 65 years and older. Duration of treatment should not exceed 14 days
Discontinue treatment if rash or feverish generalised erythema with pustules occurs at initiation of treatment