Powder for injection
1000 mg
Dosage Forms
Uses
Dose and Duration
All indications (serious Gram-negative infections resistant to
gentamicin)
Adult and child over 12 years: by IM or by
slow IV injection or by infusion over 30–60 minutes, 15 mg/kg
daily in a single or 2 divided doses (max 1.5 g/ day) for 7–10
days
Child 4 weeks–12 year: by IM or slow IV, 15–20
mg/kg/day as a single dose or divided into 2 equal doses for
7–10 days
Neonate: Give a loading dose of 10 mg/kg
followed by 7.5 mg/kg every 12 hours for 7–10 days
Premature infant: by IM or IV injection or IV
infusion over 1–2 hours, 7.5 mg every 12 hours for 7–10 days
Multi-drug resistant tuberculosis
Adult and child: 15−20 mg/kg daily. Max 750 mg
in children and 1000 mg in adults
Note: For multiple daily dose regimen, one-hour
serum concentration should not exceed 30 mg/litre; pre-dose
concentration should be less than 10 mg/litre. For once daily
dose regimen, pre-dose concentration should be less than 5
mg/litre