ACETYLCYSTEINE

Antidote for paracetamol poisoning.

Dosage Forms

▼

Solution for infusion

200 mg per 1 ml
6g/30ml solution for infusion

Uses

▼
  • Antidonte for paracetamol toxicity
  • Paracetamol over dosage

Dose and Duration

▼
Paracetamol over dosage
Child (body weight up to 20kg): Initially 150mg/kg over 1 hour, dose to be administered in 3mL/kg glucose 5%,followed by 50mg/kg over 4 hours, dose to be administered in 7mL/kg glucose 5%, then 100mg/kg over 16 hours,dose to be administered in 14mL/kg glucose 5%
Child(body weight 20–39kg ): Initially 150mg/kg over 1 hour, dose to be administered in 100ml glucose 5%,followed by 50mg/kg over 4 hours, dose to be administered in 250ml glucose 5%, then 100mg/kg over 16 hours,dose to be administered in 500ml glucose 5%
Child(body-weight 40kg and above): Initially 150mg/kg over 1 hour, dose to be administered in 200ml glucose 5% then 50mg/kg over 4 hours, to be started immediately after completion of first infusion, dose to be administered in 500ml glucose 5%, then 100mg/kg over 16 hours,to be started immediately after completion of second infusion, dose to be administered in 1litre glucose 5%
Adult(body weight 40kg and above): Initially 150mg/kg over 1 hour, dose to be administered in 200ml glucose 5% then 50mg/kg over 4 hours, to be started immediately after completion of first infusion, dose to be administered in 500ml glucose 5%, then 100mg/kg over 16 hours,to be started immediately after completion of second infusion, dose to be administered in 1litre glucose 5%
Doses at extremes of body weight: To avoid excessive dosage in obese patients, a ceiling weight of 110kg should be used when calculating the dose for paracetamol overdosage.

Side Effects

▼
  • Acidosis
  • anaphylactoid reaction
  • arrhythmias
  • malaise
  • skin reactions
  • Generalised seizures
  • Hyperhidrosis

Interactions

▼
  • Acetylcysteine might increase the vasodilatory effects of nitrates (glyceryl trinitrate)

Pregnancy

▼
  • Can be used

Breastfeeding

▼
  • Can be used

⚠️ Caution

▼
  • May slightly increase INR
  • May slightly increase prothrombin time
  • Asthma
  • Atopy